CD is a Cellular Receptor for Human Herpesvirus

Human herpesvirus 6 (HHV-6) is the etiologic agent of exanthum subitum, causes opportunistic infections in immunocompromised patients, and has been implicated in multiple sclerosis and in the progression of AIDS. Here, we show that the two major HHV-6 subgroups (A and B) use human CD46 as a cellular receptor. Downregulation of surface CD46 was documented during the course of HHV-6 infection. Both acute infection and cell fusion mediated by HHV-6 were specifically inhibited by a monoclonal antibody to CD46; fusion was also blocked by soluble CD46. Nonhuman cells that were resistant to HHV-6 fusion and entry became susceptible upon expression of recombinant human CD46. The use of a ubiquitous immunoregulatory receptor opens novel perspectives for understanding the tropism and pathogenicity of HHV-6.

Santoro F., Kennedy P., Locatelli G., Maluati M., Berger E., Lusso P. Cell Vol 99 No 7 December 23, 1999 Points to note

■ Purpose. Abstract B is an informative abstract: it contains details of what was investigated, what the findings were and what might happen in the future.

• Structure. 'B' first defines HHV-6 and explains its importance; it gives the purpose of the research (we show that...), the method {Downregulation ...) and the results; it concludes with a statement of future prospects as a result of the research.

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